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Background: Patients frequently need a rapid sequenceinduction (RSI) endotracheal intubation technique duringemergencies or electively to protect against aspiration inconditions like pregnancy, abdominal pathologies especiallyobstruction or ileus, neurologic disease, or in difficult airway.Traditionally succinylcholine has been the most commonlyused muscle relaxant for this purpose because of its fast onsetand short duration; unfortunately, it can have serious sideeffects. Rocuronium has been suggested as an alternative tosuccinylcholine for intubation.Methods: This study was done at department of anesthesiaSMBT Institute of Medical Science and Research Center,Dhamangaon Tal. Igatpuri, Nashik, Maharashtra, India. Thepatients were systematically randomized into three groups oftwenty each. Group A: Succinylcholine 1.5 mg/kg, Group B:Rocuronium bromide 0.6 mg/kg &Group C: Rocuroniumbromide 0.9 mg/kg.Intubating conditions, onset of action andadverse effects were observed.Results: It was observed that group A & group C patients hadexcellent intubation conditions with faster onset of action forgroup A patients. Adverse effects were not seen in any of thethree groups.Conclusion: Our study concludes that Succinylcholine is anideal agent for intubation in all surgical procedures. Intubatingconditions of Rocuronium bromide at a dose of 0.9mg/kg(3xED95) is comparable to Succinylcholine 1.5mg/kgat1minute. Rocuronium bromide 0.9mg/kg can be used safelyin patients where succinylcholine is contraindicated.
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Background: Motor Vehicle crashes are a remarkable reasonfor casualty all over throughout the world. By 2020, enginevehicle damage is predictable to wind up noticeably the thirddriving supporter of the international weight of illness on theglobe.Methods: The study was conducted for the period of one yearand One hundred subjects were studied at Department ofForensic Medicine &Toxicology S.N. Medical College Jodhpur.Subsequent information was collected from the study: Type ofInjuries (Grievous or Non grievous), Alcohol intake present orabsent, Number of Abrasions/ Bruises/Lacerations andGlasgow Coma Scale. Data was collected and tabulated.Statistical analysis was done. For quantitative data ‘t’ test wasused and for qualitative chi-square test was used. The ‘p’ value<0.05 is considered as statistically significant.Results: Out of total 100 patients, 55 helmeted and 35 nonhelmeted individuals, 22 and 23 persons sustained grievousinjuries respectively. In case of helmeted individuals, thepresence and absence of alcohol intake was observed in 26and 29 cases respectively. Out of 55 helmeted persons 54persons sustained abrasions, 39 had bruises and 17individuals had lacerations. The Glasgow Coma Scale (GCS)score between 3-7 and 8-15 of helmeted individuals were 20%and 80% of the individuals respectively.Conclusions: Serious injury has been found more in nonhelmeted individuals in comparison to helmeted individuals.Alcohol intake has been found more in helmeted individuals incomparison to non-helmeted individuals. The most commoninjury in helmeted individuals has been found to be abrasion.Lacerations have been found more in non-helmetedindividuals. GCS of less than 7 was found to be in more in nonhelmeted individuals in comparison to the helmeted individuals
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Background: Intrathecal xylocaine with midazolam is evermore being used for postoperative pain relief. There were littleconcern like respiratory depression and neurotoxicity with theuse of inthrathecal midazolam.Methods: In this study total 90 patients of with 30 patients ineach group using intrathecal drugs for postoperative pain reliefin Lower segment cesarean section. The three groups wereintrathecal xylocaine, intrathecal xylocaine + 1mg midazolamand intrathecal xylocaine + 2 mg midazolam respectively.Results: The demographic and hemodynamic variables werecomparable between the three groups. Only shivering andhypotension was noted with use of midazolam which was nodifferent from other groups.Conclusion: Intrathecal midazolam as an adjuvant tointrathecal xylocaine was not associated with significantadverse events or complications.
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Introduction: MI (Myocardial Infarction) remains an importanthealth problems. Various studies have recently found that uricacid may be a risk factor for cardiovascular diseases and anegative prognostic marker for mortality in subjects with preexisting congestive heart failure. Elevated serum uric acid ishighly predictive of mortality in patients with heart failure orcoronary artery disease and of cardiovascular events inpatients. Many studies including the National Health andNutrition Examination Survey (NHANES) study concluded thaturic acid is an independent risk factor for development ofcardiovascular and cerebrovascular diseases.Objective: To observe uric acid levels in patients with acutemyocardial infarction.Methodology: It was a hospital based observational studyperformed from January 2017 to July 2017 at Department ofCardiology, S. P. Medical College, Bikaner (Rajasthan) inwhich 75 patients was enrolled. Patients more than 18 years ofage diagnosed to have acute MI who presented to hospitalwithin 24 hours of onset of symptoms were included in thestudy, while patients with condition known to elevate UA (UricAcid) levels or patients receiving drugs affecting serum UAlevels & chronic alcoholics’ patients were excluded. Statisticalanalysis was done by software.Results: Patients of higher age with AMI had higher uric acidlevel as well as those who had previous history of MI hadhigher uric acid levels. Patients with AMI who died duringhospitalization had higher uric acid levels compare to alivepatients.Conclusion: SUA (Serum Uric Acid) can be used as a markerfor increased risk of acute MI. Furthermore, SUA can also beused for risk stratification after acute MI.
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Introduction: Serum high density lipoproteins levels wereestimated in type II diabetes mellitus patients with differentsystemic complications.Methods: Total 60 subjects (both male & female) of age group35-60 years were selected for the study, of which 30 subjectswere control (nondiabetic). Fasting high density lipoproteinslevels were determined by cholesterol esterase-cholesteroloxidaseperoxidase method. Proportion of differentcomplications was also determined.Conclusion: It was found that average serum values of highdensity lipoproteins in type II diabetes mellitus patients wassignificantly decreased as compared to control group. Majorityof systemic complications were cardiovascular in whichhypertension was commonest. The study indicated a positivecorrelation between serum high density lipoproteins levels andcardiovascular risk in type II diabetic patients
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Objective: To evaluate the clinical characteristics,predisposing/aggravating factors and malignant potential oforal lichen planus (OLP).Study design: This study was conducted at department ofSkin & V.D., S. P. Medical College Bikaner at outpatient basis.Results: Reticular form was the most common clinical typeseen in 64 patients (54.7%), followed by erosive in 37 (32.6%)and erythematous types in 15 (12.6%) patients. The diseasecaused pain, burning and other symptoms in 72 (75.7%)patients. Buccal mucosa was the chief site of involvement(n=29). Other sites involved were tongue (n=8), lips (n=21),palate (n=3) and floor of mouth (n=0). Stress, spicy foods andpoor oral hygiene aggravated disease in most (n=77) of thepatients. A malignant transformation rate of 0.07% wasobserved.
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Background: Pregnancy related acute kidney injury(PRAKI) is common in developing countries like India. The aim of the study was to identify the etiology, prognosis, management and to have preventable measures, to improve the maternal and fetal outcome. Methods: The study was conducted in S.P. Medical College& Hospital – Obstetrics and Gynecology Department from July 2017 to December 2017.A total of 22 cases has been studied. Results: The incidence of PRAKI was 1.3% in our hospital. Pregnancy induced hypertension, pre-eclampsia, eclampsia was found to be commonest cause. Incidence of PRAKI was high in third trimester. The outcome was favorable with complete recovery in 45.47% patients. Conclusion: The low incidence of PRAKI was probably due to improved obstetric practices. Future research is further needed, to decrease the incidence.